Figure 3.

Effect of rimonabant (0.5 mg kg⁻¹ i.p.) and SR144528 (1 mg kg⁻¹ i.p.) on (a) anti-oedemigen and (b) anti-nociceptive effect evoked by URB602 (10 mg kg⁻¹ i.p.). Antagonists were administered 15 min before the drug and behavioural evaluations were assessed 2 h (oedema) and 5 h (thermal hypersensitivity) after carrageenan. Data represent mean±s.e.m. of 8–10 mice. ^***P<0.001, ^*P<0.05 versus non-inflamed, °°°P<0.001, °°P<0.01 versus inflamed. URB602, [1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester.