Table 1.
Effect of rimonabant administration (0.5 mg kg−1) on URB602 (20 mg kg−1)-induced psychoactive effects
| Vehicle | URB602 | Rimonabant/URB602 | |
|---|---|---|---|
| Body temperature (°C) | 38.7±0.12 | 37.66±0.05* | 38.9±0.06° |
| Nociceptive threshold (s) | 8.83±0.14 | 13.73±0.15* | 8.30±0.10° |
| Spontaneous locomotor activity (s) | 361.2±15.85 | 83.67±22.2* | 130.0±18.00* |
| Immobility on a ring (%) | 15.0±2.04 | 53.33±1.67* | 12.0±4.00° |
Values shown in the table are the mean±s.e.m. *P<0.001 versus vehicle; °P<0.001 versus URB602.
Abbreviation: URB602, [1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester.