Effect of PSNCBAM-1 and SR141716A on acute feeding (a) and body weight (b) in male SD rats. Compounds were administered by i.p. injection before the start of the dark phase. Food intake was monitored by weighing the feeding jars at 1, 2, 4, 6 and 24 h and animals were weighed at 24 h. Results are means±s.e.m. for groups of six rats. *P<0.05 and **P<0.01, analysis of variance followed by Dunnett's multiple comparison test. i.p., intraperitoneal; PSNCBAM-1, 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea; SD, Sprague–Dawley; SR141716A, N-(piperidin-1-yl)-5-(4-cholrophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide.