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Atypical cannabinoids stimulate GPR55 GTPγS activity. Membranes from HEK293T cells expressing human recombinant GPR55 were utilized for GTPγS activity as described in Materials and methods. (a) Abnormal cannabidiol and (b) the synthetic abnormal cannabidiol analogue O-1602 stimulate GTPγS activity with similar potency. Data points represent means±s.e.mean of n=3 experiments.
