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. 1976 Jan 1;143(1):73–84. doi: 10.1084/jem.143.1.73

Studies on the role of the host immune response in recovery from Friend virus leukemia. I. Antiviral and antileukemia cell antibodies

PMCID: PMC2190092  PMID: 1244422

Abstract

The humoral immune response to Friend virus leukemia was studied in congenic F1 mice differing in their incidence of recovery from leukemia. Antiviral neutralizing antibodies rose in titer in vivo concurrently with disappearance of viremia and fall in spleen virus levels. Cytotoxic antileukemia cell antibodies also appeared at this time. Passive transfer of these antibodies could inactivate low numbers of leukemia cells in vivo; however, mice of both high and low recovery genotypes produced antibodies in equal titer and recovered from viral infection in spite of striking differences in recovery from leukemic splenomegaly. Mice lacking C57BL genes did not produce antibodies or recover from viremia except in rare instances. Recovery from splenomegaly was found to be influenced by three or more C57BL genes independent of the H-2 complex.

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Selected References

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  1. AXELRAD A. A., STEEVES R. A. ASSAY FOR FRIEND LEUKEMIA VIRUS: RAPID QUANTITATIVE METHOD BASED ON ENUMERATION OF MACROSCOPIC SPLEEN FOCI IN MICE. Virology. 1964 Nov;24:513–518. doi: 10.1016/0042-6822(64)90199-0. [DOI] [PubMed] [Google Scholar]
  2. Axelrad A. A., Thomson S. Radiosensitivity and growth of Friend leukemia virus studied with the spleen focus assay method. Int J Cancer. 1969 Mar 15;4(2):179–193. doi: 10.1002/ijc.2910040208. [DOI] [PubMed] [Google Scholar]
  3. Boyse E. A., Stockert E., Old L. J. Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody. Proc Natl Acad Sci U S A. 1967 Sep;58(3):954–957. doi: 10.1073/pnas.58.3.954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brier A. M., Wohlenberg C., Rosenthal J., Mage M., Notkins A. L. Inhibition or enhancement of immunological injury of virus-infected cells. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3073–3077. doi: 10.1073/pnas.68.12.3073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brodeur B. R., Merigan T. C. Mechanism of the suppressive effect of interferon on antibody synthesis in vivo. J Immunol. 1975 Apr;114(4):1323–1328. [PubMed] [Google Scholar]
  6. Cerny J., Essex M., Rich M. A., Hardy W. D., Jr Expression of virus-associated antigens and immune cell functions during spontaneous regression of the Friend viral murine leukemia. Int J Cancer. 1975 Feb 15;15(2):351–365. doi: 10.1002/ijc.2910150219. [DOI] [PubMed] [Google Scholar]
  7. Chesebro B., Wehrly K., Stimpfling J. Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex. J Exp Med. 1974 Dec 1;140(6):1457–1467. doi: 10.1084/jem.140.6.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chesebro B., Wehrly K. Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity. J Exp Med. 1976 Jan 1;143(1):85–99. doi: 10.1084/jem.143.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fefer A. Immunotherapy and chemotherapy of Moloney sarcoma virus-induced tumors in mice. Cancer Res. 1969 Dec;29(12):2177–2183. [PubMed] [Google Scholar]
  10. Fefer A., McCoy J. L., Glynn J. P. Induction and regression of primary moloney sarcoma virus-induced tumors in mice. Cancer Res. 1967 Sep;27(9):1626–1631. [PubMed] [Google Scholar]
  11. Fefer A., McCoy J. L., Perk K., Glynn J. P. Immunologic, virologic, and pathologic studies of regression of autochthonous Moloney sarcoma virus-induced tumors in mice. Cancer Res. 1968 Aug;28(8):1577–1585. [PubMed] [Google Scholar]
  12. Gresser I. Antitumor effects of interferon. Adv Cancer Res. 1972;16:97–140. doi: 10.1016/s0065-230x(08)60339-5. [DOI] [PubMed] [Google Scholar]
  13. Harada M., Pearson G., Redmon L., Winters E., Kasuga S. Antibody production and interaction with lymphoid cells in relation to tumor immunity in the Moloney sarcoma virus system. J Immunol. 1975 Apr;114(4):1318–1322. [PubMed] [Google Scholar]
  14. Hellström I., Hellström K. E., Evans C. A., Heppner G. H., Pierce G. E., Yang J. P. Serum-mediated protection of neoplastic cells from inhibition by lymphocytes immune to their tumor-specific antigens. Proc Natl Acad Sci U S A. 1969 Feb;62(2):362–368. doi: 10.1073/pnas.62.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hirsch M. S., Ellis D. A., Proffitt M. R., Black P. H. Effects of interferon on leukaemia virus activation in graft versus host disease. Nat New Biol. 1973 Jul 25;244(134):102–103. doi: 10.1038/newbio244102a0. [DOI] [PubMed] [Google Scholar]
  16. KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
  17. Lamon E. W., Klein E., Andersson B., Fenyö E. M., Skurzak H. M. The humoral antibody response to a primary viral neoplasm (MSV) through its entire course in BALB-c mice. Int J Cancer. 1973 Nov 15;12(3):637–645. doi: 10.1002/ijc.2910120312. [DOI] [PubMed] [Google Scholar]
  18. Lavrin D. H., Herberman R. B., Nunn M., Soares N. In vitro cytotoxicity studies of murine sarcoma virus-induced immunity in mice. J Natl Cancer Inst. 1973 Nov;51(5):1497–1508. doi: 10.1093/jnci/51.5.1497. [DOI] [PubMed] [Google Scholar]
  19. Law L. W., Ting R. C., Stanton M. F. Some biologic, immunogenic, and morphologic effects in mice after infection with a murine sarcoma virus. I. Biologic and immunogenic studies. J Natl Cancer Inst. 1968 May;40(5):1101–1112. [PubMed] [Google Scholar]
  20. Lewis M. G., Ikonopisov R. L., Nairn R. C., Phillips T. M., Fairley G. H., Bodenham D. C., Alexander P. Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Br Med J. 1969 Sep 6;3(5670):547–552. doi: 10.1136/bmj.3.5670.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  22. Lilly F. The effect of histocompatibility-2 type on response to friend leukemia virus in mice. J Exp Med. 1968 Mar 1;127(3):465–473. doi: 10.1084/jem.127.3.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Lindahl P., Leary P., Gresser I. Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci U S A. 1972 Mar;69(3):721–725. doi: 10.1073/pnas.69.3.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Mortensen R. F., Ceglowski W. S., Friedman H. Leukemia virus-induced immunosuppression. X. Depression of T cell-mediated cytotoxicity after infection of mice with Friend leukemia virus. J Immunol. 1974 Jun;112(6):2077–2086. [PubMed] [Google Scholar]
  25. ODAKA T., EDAKA T., YAMAMOTTO T. Inheritance of susceptibility to Friend mouse leukemia virus. Jpn J Exp Med. 1962 Oct;32:405–413. [PubMed] [Google Scholar]
  26. OLD L. J., BOYSE E. A., STOCKERT E. TYPING OF MOUSE LEUKAEMIAS BY SEROLOGICAL METHODS. Nature. 1964 Feb 22;201:777–779. doi: 10.1038/201777a0. [DOI] [PubMed] [Google Scholar]
  27. Pearson G. R., Redmon L. W., Bass L. R. Protective effect of immune sera against transplantable Moloney virus-induced sarcoma and lymphoma. Cancer Res. 1973 Jan;33(1):171–178. [PubMed] [Google Scholar]
  28. Pierce G. E. Enhanced growth of primary Moloney virus-induced sarcomas in mice. Int J Cancer. 1971 Jul 15;8(1):22–31. doi: 10.1002/ijc.2910080104. [DOI] [PubMed] [Google Scholar]
  29. Pollack S., Heppner G., Brawn R. J., Nelson K. Specific killing of tumor cells in vitro in the presence of normal lymphoid cells and sera from hosts immune to the tumor antigens. Int J Cancer. 1972 Mar 15;9(2):316–323. doi: 10.1002/ijc.2910090209. [DOI] [PubMed] [Google Scholar]
  30. Rager-Zisman B., Bloom B. R. Immunological destruction of herpes simplex virus I infected cells. Nature. 1974 Oct 11;251(5475):542–543. doi: 10.1038/251542a0. [DOI] [PubMed] [Google Scholar]
  31. Rossi G. B., Cudkowicz G., Friend C. Transformation of spleen cells three hours after infection in vivo with Friend leukemia virus. J Natl Cancer Inst. 1973 Jan;50(1):249–254. doi: 10.1093/jnci/50.1.249. [DOI] [PubMed] [Google Scholar]
  32. Steeves R. A. Cellular antigen of Friend virus-induced leukemias. Cancer Res. 1968 Feb;28(2):338–342. [PubMed] [Google Scholar]
  33. Svehag S. E. Formation and dissociation of virus-antibody complexes with special reference to the neutralization process. Prog Med Virol. 1968;10:1–63. [PubMed] [Google Scholar]
  34. TENNANT J. R. Derivation of a murine lymphoid leukemia virus. J Natl Cancer Inst. 1962 Jun;28:1291–1303. [PubMed] [Google Scholar]
  35. Tamerius J. D., Hellström I. In vitro demonstration of complement-dependent cytotoxic antibodies to Moloney sarcoma cells. J Immunol. 1974 Jun;112(6):1987–1996. [PubMed] [Google Scholar]

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