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. Author manuscript; available in PMC: 2008 Jan 10.
Published in final edited form as: Gastroenterology. 2006 Oct 21;132(1):119–126. doi: 10.1053/j.gastro.2006.10.034

Figure 1. Sequence readout by the resequencing “Jaundice Chip”.

Figure 1

Panel A displays the hybridization cartridge assembled by Affymetrix, Inc., which contains a solid support featuring 25-mer probes designed to sequence 26,725 nucleotides (bases) of SERPINA1, JAG1, ATP8B1, ABCB11, and ABCB4. Panel B shows signals obtained from a high-resolution scanning after hybridization of a chip with amplicons from a subject. In the top portion of panel C, magnification of a region of the chip shows that the brightest signal for each set of four 25-mer probes for each column identifies a base. In the lower panel, identical base calls were made by standard capillary sequencing methodology.