Table I.

Parameter Estimates (95% CI) for the Final Population Pharmacokinetic Model of Buprenorphine

	Original Data		1,000 Bootstrap Replicates
	Typical Estimate	Inter-Animal Variability ω2	Typical Estimate	Inter-Animal Variability ω2
Cl (ml/min)	18 (16.3–19.7)	0.128 (0.108–0.148)	18 (16.1–19.9)	0.125 (0.086–0.164)
V1 (ml)	110 (77–142)	0.936 (0.348–1.52)	108 (65–150)	0.914 (0.267–1.56)
V2 (ml)	370 (312–428)	0.274 (0.117–0.431)	400 (320–480)	0.353 (−0.041–0.745)
V3 (ml)	1,200 (1,009–1,391)	0.337 (0.200–0.474)	1,181 (907–1,455)	0.239 (0.063–0.415)
Q2 (ml/min)	30 (26–34)	–	30.3 (26–35)	–
Q3 (ml/min)	11 (9.6–12.4)	0.172 (0.094–0.250)	10.2 (7.8–12.6)	0.128 (−0.048–0.304)
Proportional error (%)	0.032 (0.022–0.042)			0.033 (0.021–0.045)