Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2001 Apr 30;153(3):517–528. doi: 10.1083/jcb.153.3.517

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Proposed events that drive the production of lagging chromosomes in anaphase through merotelic kinetochore orientation. (a) Spindle disassembly induced by the nocodazole mitotic block promotes the expansion and curvature of the outer domain of kinetochores around their centromeric DNA. (b) A slow compaction of the kinetochore outer domain when the spindle reassembles after nocodazole removal may promote the unusually high frequency of merotelic kinetochore orientation that occurs by the time chromosomes have moved to near the spindle equator in prometaphase. (c) A merotelically oriented kinetochore does not move poleward like normal kinetochores at anaphase because it does not split apart like sister kinetochores at anaphase onset, but instead remains under tension and becomes further stretched by poleward forces directed along its kinetochore microtubules to opposite poles.