Figure 3.

Autopsy results from LKL subject III-6. (A) Tau-2 immunopositive neurons in the substantia inomminata. Dense, tau-positive, cytoplasmic inclusions are seen in multiple neurons as well as neuropil threads (magnification ×219). The section was stained by antibody tau-2 (Sigma, diluted 1:12,000) with ABC-peroxidase-diaminobenzidine and counterstained with hematoxylin. (B) Dystrophic processes of neuritic plaques, neurofibrillary tangles, and neuropil threads in the entorhinal cortex. Staining was with tau-2 as in A (magnification ×219). (C) Aβ-positive plaques with and without dense cores in superior temporal cortex (magnification ×109). Staining was with anti-Aβ antibody 10D5 (Athena Neurosciences, San Francisco, diluted 1:5,000) as described in A above. (D) Higher magnification of superior temporal cortex showing two Aβ-positive plaques with dense cores (magnification ×219). Staining was as in C above.