Figure 3.

(A) Effects of ventral tegmental area (VTA) burst stimulation on medial prefrontal cortex (mPFC) and somatosensory cortex (SSCx) cytochrome oxidase I (CO-I) activity. A significantly higher CO-I level was found in the medial PFC of adult (postnatal day > 62) neonatal ventral hippocampal lesioned animals when VTA stimulation was delivered (*** p< .002, compared with sham-operated, Tukey post hoc test after significant analysis of variance assessment). In contrast, VTA stimulation failed to modify the CO-I activity in the SSCx. (B) Effect of VTA stimulation on CO-I levels in three different subcortical regions that receive important DA inputs: the nucleus accumbens core (NAc) and shell (NAs), and the dorsal striatum (D-Str). No statistical differences were observed between sham-operated and NVHL animals in any of these regions.