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. Author manuscript; available in PMC: 2008 Jan 10.
Published in final edited form as: Biol Psychiatry. 2006 Jun 14;60(6):585–590. doi: 10.1016/j.biopsych.2006.03.030

Figure 4.

Figure 4

Medial prefrontal cortex (PFC) cytochrome oxidase I (CO-I) ratio induced by one (S1; 15 train of 5 pulses at 20 Hz every 30 s) and three (S3; 3 repetitions of S1 every 20 min) sets of repetitions of ventral tegmental area (VTA) stimulation in adult (A) and prepubertal (B) sham-operated and neonatal ventral hippocampal lesioned (NVHL) animals. An opposite PFC CO-I ratio response to S1 VTA stimulation was found in adult sham-operated and lesioned animals whereas no consistent changes were observed in the PFC of prepubertal rats. Increasing the repetitions of burst stimulation to S3 effectively enhanced the ratio of CO-I level in the adult PFC of sham-operated animals as compared with that induced with S1. In contrast to what was observed in the sham-operated group, S3 stimulation failed to further increase the CO-I ratio obtained in the PFC of adult NVHL animals with S1. PD, postnatal day; NS, no stimulation.