Curves are displayed as a function of parameter cutoff criteria for detection of plus disease: (A) arteriolar integrated curvature (IC), (B) arteriolar diameter, (C) arteriolar tortuosity index (TI), (D) venular IC, (E) venular diameter, (F) venular TI, (G) Linear Combination I (arteriolar IC, venular IC and venular diameter) and (H) Linear Combination II (arteriolar IC, arteriolar TI, venular IC, venular diameter, and venular TI).