Table 2.

Computer-based system sensitivity, specificity, and receiver operating characteristic area under the curve (AUC) for detection of plus disease, compared to the reference standard of majority vote among 22 recognized ROP experts.

System Parameter	Sensitivity*	Specificity*	AUC (SE†)	AUC p-value‡
Arteriolar Integrated Curvature	0.760	0.760	0.817 (0.085)	0.002
Arteriolar Diameter	0.590	0.590	0.560 (0.102)	0.559
Arteriolar Tortuosity Index	0.700	0.700	0.707 (0.099)	0.045
Venular Integrated Curvature	0.760	0.760	0.853 (0.072)	0.001
Venular Diameter	0.760	0.760	0.821 (0.082)	0.002
Venular Tortuosity Index	0.640	0.640	0.744 (0.089)	0.018
Linear Combination I§	0.938	0.938	0.956 (0.036)	<0.001
Linear Combination II	0.938	0.938	0.967 (0.0310)	<0.001

^*For the computer-based system, values at the intersection points of the sensitivity and specificity curves in Figure 3 are displayed in this table.

^†SE, Standard Error.

^‡Null hypothesis: true area = 0.5 at level of significance 0.05.

^§Comprising arteriolar integrated curvature (IC), venular IC, and venular diameter.

^||Comprising arteriolar integrated curvature (IC), arteriolar tortuosity index (TI), venular IC, venular diameter, and venular TI.