Nerve function and antioxidant potential was assessed using tail flick latency (TF) at 8 and 12 weeks (A), Sciatic Motor Nerve Conduction Velocity (SMNCV) at 12 and 24 weeks (B), and DRG TRAP at 24 weeks (C). In A, TF latencies are significantly longer in db/db, *p < 0.001. In B, a significant difference in SMNCV is only detected at 24 weeks between the db+ and db/db SOD2+/−mice (*p < 0.001). In C, TRAP was significantly lower in db/db mice compared with db+ (+p<0.05). n=10 for each experimental group.