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Change of linearity of the DNA double helix during molecular dynamics simulations of the tetramer bound to the DNA in the H14 mode with the p53 interacting with four p53REs (A), p21-5′ binding site; (B) GADD45; (C) pDINP1; and (D) p53AIP1. A potential mechanism in these simulations for cooperative p53–DNA interaction and DNA bending is illustrated in box E.
