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. 2007 Nov 5;35(22):7733–7747. doi: 10.1093/nar/gkm890

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Structural details of the potential H14 binding mode, in which two swapped copies of p53 dimer bind DNA symmetrically in respect to full-site palindrome. p53-tetramer–Puma BS2 complex is used here. Chains binding DNA specifically at quarter-sites one and four are the B chains in the p53-trimer–DNA complex. B1 and B2 are used to term their position in two dimers, respectively. The A chains assist in the DNA recognition and provide tetramer stability. A1 and A2 are used to name the chain position. (A) A view along the DNA chain. (B) A view perpendicular to the DNA chain, in which the p53 tetramer is inside the DNA loop. (C) A view from the top of the complex illustrating the arrangement of the core domain tetramer. (D) Atomic details of the salt bridges stabilizing the p53 tetramer.