Table 1.
Mouse models that alter p53 activity
| Mouse Model | Mutation type | Aging phenotype | References |
|---|---|---|---|
| Ku80−/− | Ku80 null | Enhanced | (61,66) |
| mTR−/− | Telomerase null | Enhanced | (71–73) |
| Zmpste24−/− | Zmpste24 null | Enhanced | (79) |
| Brca1Δ11/Δ11 | Hypomorphic mutation | Enhanced | (84,85) |
| p53+/m | p53 exon 1-6 plus 23 upstream genes deleted | Enhanced | (4,5) |
| P+/+mice | Expression of p53 isoform p44 | Enhanced | (6) |
| ‘Super–p53’ mouse | Extra copy of p53 gene | Normal | (89–91) |
| Mdm2puro/Δ7–12 | One null allele and another hypomorphic allele | Normal | (95) |