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The Nucleolus serves as a storage of PARP-1 and PARP-2 to cope with heavy DNA damage. (A and C) Live cell imaging of microirradiated Hela cells sensitized with Hoechst 33285. Microirradiation of Hoechst sensitized cells leads to massive recruitment and temporary depletion of PARP-1 and PARP-2 from the nucleolus. (B and D) Quantitative evaluation of recruitment and nucleolar depletion kinetics. Error bars represent the SEM. Scale bar, 5 μm.
