Table 1.

Premature aging syndromes, associated genetic mutations and affected DNA damage repair pathway

Disease	Affected DNA repair pathway	Gene(s) mutated
Xeroderma Pigmentosa	Nucleotide excision repair	XP(A-G)
Cockayne syndrome	Nucleotide excision repair	CSA & CSB
Trichothiodystrophy	Nucleotide excision repair	Various XP and CS related
Werner syndrome	DSB repair homologous Rec.	WRN (a RECQ family member)
Rothmund–Thomson syndrome	DSB repair homologous Rec.	RECQ4
Bloom	DSB repair homologous Rec.	BLM (a RECQ family member)
Ataxia Telangiectasia	Global DSB repair	ATM (a PI3K)