Table 6.
Comparison of baseline clinical parameters across three groups of estradiol-treated women categorized by sex hormone changes in response to ET
| Clinical factors | Free E2 increased, free T not changed, SHBG not changed (n = 14) | Free E2 increased, free T not changed, SHBG increased (n = 33) | Free E2 increased, free T decreased, SHBG increased (n = 39) | P value for difference |
|---|---|---|---|---|
| Age (yr) | 57.4 (1.7) | 59.9 (1.1) | 62.7 (1.0) | 0.02 |
| BMI (kg/m2) | 29.6 (1.5) | 27.3 (1.0) | 30.5 (0.9) | 0.05 |
| IMT (μm) | 758.8 (29.3) | 740.3 (19.1) | 761.6 (17.6) | 0.70 |
| LDL-C (mg/dl) | 168.3 (7.9) | 165.1 (5.2) | 167.4 (4.7) | 0.92 |
| HDL-C (mg/dl) | 54.3 (3.2) | 57.0 (2.1) | 51.5 (1.9) | 0.17 |
| TG (mg/dl) | 144.7 (17.8) | 147.2 (11.6) | 180.6 (10.6) | 0.07 |
| Glucose (mg/dl) | 87.7 (2.9) | 85.2 (1.8) | 92.6 (1.7) | 0.01 |
| Insulin (mg/dl) | 7.8 (1.3) | 8.0 (0.8) | 10.8 (0.7) | 0.03 |
| Hemoglobin A1C (%) | 4.9 (0.2) | 4.9 (0.1) | 5.1 (0.1) | 0.41 |
| E2 (pg/ml) | 17.8 (1.7) | 17.6 (1.1) | 21.0 (1.0) | 0.07 |
| Free E2 (pg/ml) | 0.5 (0.06) | 0.5 (0.04) | 0.6 (0.03) | 0.02 |
| T (ng/dl) | 17.3 (2.5) | 16.6 (1.6) | 25.5 (1.5) | 0.0002 |
| Free T (pg/ml) | 3.2 (0.5) | 2.9 (0.32) | 5.2 (0.3) | <0.0001 |
| Androstenedione (pg/ml) | 589.3 (68.3) | 500.5 (44.5) | 581.9 (40.9) | 0.34 |
| DHEA (ng/ml) | 2.6 (0.4) | 2.1 (0.3) | 2.4 (0.3) | 0.59 |
| SHBG (nmol/liter) | 30.8 (4.1) | 38.7 (2.7) | 29.0 (2.4) | 0.03 |
E2, Estradiol; T, testosterone.