Table 3.
HRs of total testosterone and bioavailable testosterone for all-cause mortality
| Hormone quartile | Median hormone level (ng/dl) | Model 1 HR (95% CI)a | Model 2 HR (95% CI)b | Model 3 HR (95% CI)c |
|---|---|---|---|---|
| Testosterone (ng/dl) | ||||
| Q4 (>370) | 436 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Q3 (300–370) | 331 | 0.90 (0.71, 1.15) | 0.95 (0.74, 1.21) | 0.93 (0.73, 1.19) |
| Q2 (241–299) | 273 | 1.04 (0.82, 1.32) | 1.14 (0.89, 1.45) | 1.15 (0.90, 1.47) |
| Q1 (<241) | 204 | 1.29 (1.02, 1.64) | 1.42 (1.11, 1.82) | 1.44 (1.12, 1.84) |
| PTREND | 0.026 | 0.003 | 0.002 | |
| Bioavailable T (ng/dl) | ||||
| Q4 (>117) | 135 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Q3 (96–117) | 105 | 0.93 (0.71, 1.22) | 0.96 (0.73, 1.27) | 0.94 (0.72, 1.24) |
| Q2 (78–95) | 87 | 1.11 (0.85, 1.44) | 1.17 (0.89, 1.53) | 1.16 (0.89, 1.52) |
| Q1 (<78) | 65 | 1.46 (1.12, 1.89) | 1.52 (1.17, 1.99) | 1.50 (1.15, 1.96) |
| PTREND | 0.001 | <0.001 | <0.001 |
Ref, Reference category.
a
Model 1, adjusted for age.
b
Model 2, adjusted for age, BMI, and waist to hip ratio.
c
Model 3, model 2 + alcohol use, current smoking, and exercise.