Table 5.
HRs of low total testosterone and low bioavailable testosterone for cause-specific mortality by years of follow-up
| Cause of death | 0–20 yr follow-up
|
5–20 yr follow-up
|
||
|---|---|---|---|---|
| n | HR (95% CI) | n | HR (95% CI) | |
| Low total testosteronea | ||||
| All-cause | 529 | 1.38 (1.12, 1.69) | 409 | 1.60 (1.27, 2.02) |
| CVD | 264 | 1.38 (1.02, 1.85) | 199 | 1.73 (1.23, 2.45) |
| Cancer | 127 | 1.34 (0.89, 2.00) | 90 | 1.22 (0.75, 1.99) |
| Respiratory disease | 54 | 2.29 (1.25, 4.20) | 46 | 2.67 (1.37, 5.20) |
| Other | 96 | 1.13 (0.68, 1.88) | 83 | 1.51 (0.89, 2.56) |
| Low biotestosteroneb | ||||
| All-cause | 529 | 1.44 (1.19, 1.74) | 409 | 1.44 (1.16, 1.80) |
| CVD | 264 | 1.36 (1.04, 1.79) | 199 | 1.39 (1.01, 1.92) |
| Cancer | 127 | 1.50 (0.99, 2.26) | 90 | 1.38 (0.82, 2.31) |
| Respiratory disease | 54 | 1.84 (1.03, 3.28) | 46 | 1.65 (0.86, 3.14) |
| Other | 96 | 1.43 (0.91, 2.24) | 83 | 1.56 (0.96, 2.53) |
Adjusted for age, BMI, waist to hip ratio, alcohol use, current smoking, and exercise.
a
Reference is total testosterone 241 ng/dl or greater.
b
Reference is bioavailable testosterone 78 ng/dl or greater.