Table 1.
Kinetic parameters of mutations at the upper hinge position in A: heteromeric Kir4.1/Kir5.1, and B: homomeric Kir4.1
| Po | MOT | MCT | MBD | |
|---|---|---|---|---|
| A | ||||
| Kir4.1/Kir5.1 | 0.35 ± 0.05 | 2.30 ± 0.01 | 2.98 ± 0.01 | 14.77 ± 11.0 |
| Kir4.1(T154G)/Kir5.1 | 0.19 ± 0.02 | 1.08 ± 0.01 | 4.44 ± 0.02 | 8.6 ± 5.2 |
| Kir4.1/Kir5.1(S157G) | 0.32 ± 0.04 | 1.97 ± 0.01 | 2.30 ± 0.02 | 14.77 ± 8.7 |
| B | ||||
| Kir4.1 | 0.45 ± 0.05 | 97.19 ± 8.95 | 22.87 ± 2.39 | |
| Kir4.1(T154G) | 0.36 ± 0.04 | 14.82 ± 2.75 | 21.29 ± 3.68 | |
MOT mean open time, MCT mean closed time, and MBD mean burst duration. Values are in ms; n = 5–8