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X-ray crystallographic structure of 2C TCR with mutated residues highlighted. The 2C TCR structure (6) is shown with residues isolated as mutants in the yeast display system highlighted. The FR2 interface mutation is colored green. The CDR3 interface mutations are colored orange. First-framework-region (FR1) mutations proximal to the Cβ “knob” (in the full TCR) are colored purple. There are three negatively charged Cβ knob residues (Glu-221, Glu-222, and Asp-223) indicated in red.
