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IκBα over-expression permanently inhibits TNFα and IL-6 production. Shown is the effect of infection of rheumatoid synovial cells with 40:1 of either Adv0 or AdvIκBα on the spontaneous production of TNFα (A) or IL-6 (B) over time. Symbols denote uninfected (■), Adv0-infected (♦), or AdvIκBα-infected (●) cells. Shown is a representative of three independent experiments.
