Figure 7.

Effect of AdvIκBα infection on MMP and TIMP production in rheumatoid synovial cell cultures in which IL-1 and/or TNFα were neutralized. Rheumatoid synovial cells were either left uninfected or infected with 40:1 of Adv0 or AdvIκBα. After the virus was taken off and culture medium was added, the cells in each of the three categories either were left untreated or were treated with 20 μg/ml of the IL-1 receptor antagonist and/or 20 μg/ml of the A2 anti-TNFα antibody. The spontaneous production of MMP 1 (A), MMP 3 (B), and TIMP-1 (C) was assayed after 2 days. Shown is a representative of three complete experiments.