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. 2001 Jun 11;153(6):1187–1198. doi: 10.1083/jcb.153.6.1187

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Identification and characterization of eis mutants that yield enhanced insulin secretion. (A) Filter blot assay for immunoreactive insulin secretion from the nine colonies obtained by genetic screening, which represent disruptions of six independent genes. Five of these proved to be genes in the vps pathway as indicated. (B) Five eis/vps mutants and a vps10-null mutant were replica plated and tested by filter blot assay for immunoreactive insulin secretion (top panel) and CPY secretion (bottom panel). Note that like the eis/vps mutants obtained by genetic screen vps10 dramatically increases CPY secretion, but the effect on ICFP secretion is minimal.