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. 2001 Jun 11;153(6):1239–1250. doi: 10.1083/jcb.153.6.1239

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Bub1^K872R is functional in the spindle checkpoint. (A) Bub1-depleted extracts containing mock, Bub1, or Bub1^K872R translation as indicated on the left were incubated with sperm nuclei and nocodazole. Samples were taken for histone H1 kinase measurement as described in the legend to Fig. 2. The level of added protein compared with the endogenous protein is indicated on the left. Both Bub1 and Bub1^K872R restore the checkpoint when added at 50–100% of the level of the endogenous protein. (B) Immunoblot of Bub1 for samples used in A.