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. 2001 Jun 11;153(6):1209–1226. doi: 10.1083/jcb.153.6.1209

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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CeCENP-A and CeCENP-C colocalize to the diffuse kinetochores of one-cell stage C. elegans embryos. (A) Wild-type embryos were stained to visualize DNA (cyan), MTs (red), Ce-CENP-A, and CeCENP-C. Different stages during the first division of the C. elegans embryo are shown. The sperm-derived pronucleus with associated centrosomal asters is to the right and the oocyte-derived pronucleus to the left in the early prophase and prophase panels. The weak spindle pole staining in the Ce-CENP-A metaphase and anaphase panels is nonspecific. (B) Higher magnification panels of nuclei stained for DNA and CeCENP-C. The panels on the left show a prophase pronucleus just before pronuclear meeting. CeCENP-C localizes to a patchy stripe that runs along the partially condensed chromosomes. The panels on the right show a pronucleus after the pronuclei have met and the nuclear envelope has broken down. By this time, CeCENP-C localizes to two plates on opposite faces of the fully condensed chromosomes. All images are projections of three-dimensional stacks. Bars: (A) 5 μm; (B) 1 μm.