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. 2001 Jun 11;153(6):1209–1226. doi: 10.1083/jcb.153.6.1209

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Depletion of CeCENP-A or CeCENP-C results in a similar chromosome segregation defect. The panels summarize videos of embryos expressing GFP-histone. Stills from a wild-type embryo (left), a CeCENP-A–depleted embryo (middle), and a CeCENP-C–depleted embryo (right) are shown. The time in the upper right hand corner of each panel is seconds after NEBD. All sequences are oriented with embryo anterior on the left and embryo posterior, determined by the position of sperm entry, on the right. In CeCENP-A– or CeCENP-C–depleted embryos, the maternal and paternal chromosomes form separate compact chromosomal masses that fail to distribute over the spindle equator and fail to segregate at anaphase. The insets show a face on view of metaphase spindles. Insets are magnified 3.4-fold relative to the other panels. Online supplemental videos are available at http://www.jcb.org/cgi/content/full/153/6/1209/DC1. Bar, 5 μm.