Figure 5.

Comparison of antitumor effects of T138067 with those of paclitaxel and vinblastine against human tumor xenografts in athymic nude mice. (A) CCRF-CEM lymphoblastic leukemia tumors. (B) CCRF-CEM/VBL₁₀₀ MDR tumors. Tumor cells were s.c. implanted in athymic nude mice on day 0. T138067 (40 mg/kg; ●); paclitaxel (30 mg/kg; ▴); vinblastine (1 mg/kg; □), or a vehicle control (■) were administered i.p. on days 5, 12, and 19 (indicated by the arrows) after tumor implantation. Tumor size at days 5, 10, 15, 20, and 25 is expressed as mean ± SEM (n = 5).