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. 1999 Feb 1;189(3):587–592. doi: 10.1084/jem.189.3.587

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The priming of Th1 cells by CD8α⁺ DCs is IL-12 dependent. (a and b) CD8α⁺ or CD8α⁻ DCs or both subsets, isolated from p40-deficient (KO) or wild-type (WT) mice, were loaded with KLH and injected into the footpads of Balb/c mice. (c and d) Balb/c mice were injected in the footpads with CD8α⁺ or CD8α⁻ DCs with or without four daily injections of 200 ng i.p. rmIL-12. LN cells were harvested 5 d later and cultured with 10 μg/ml antigen. The production of IFN-γ and IL-4 was measured in the supernatants, as indicated in Materials and Methods. Similar data were obtained in all four experiments performed.