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. 1999 Feb 1;189(3):553–562. doi: 10.1084/jem.189.3.553

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Effect of depleting NK1.1⁺ cells before immunization on systemic levels of OVA-specific IgE and IgG2a. Mice were immunized on day 0 and challenged daily with aerosolized OVA on days 14–20. Plasma was collected 8 or 30 h after last OVA challenge. Immunization and allergen exposure of IgG-treated animals induced both allergen-specific IgE and IgG2a. In corresponding NK1.1⁺ cell–depleted animals, this induction of allergen-specific IgE and IgG2a was significantly suppressed (**P < 0.01 and *P < 0.05, respectively). Solid bars, mean (n = 13–14 per group); IgG, IgG-treated animals; NK1.1, mAb NK1.1–treated animals.