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. 1999 Feb 15;189(4):673–682. doi: 10.1084/jem.189.4.673

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Level of Ig subclass in H1R^−/− mice before and after immunization with the T cell–dependent antigen, OVA. (A) Levels of serum Ig subclass in unimmunized mice. Serum Ig levels in 8–10-wk-old H1R^−/− mice (−/−) and their wild-type littermates were determined by isotype-specific ELISA. •, control (+/+); ○, mutant (−/−) mice. Shown are the results from five mice of each group. (B) Levels of anti-OVA antibody titers of each Ig isotype after secondary immunization. Serum samples were collected 2 wk after the second immunization. Titers of OVA-specific antibodies were determined by isotype-specific ELISA. Serum antibody levels are expressed as OD₄₅₀. Shown are the results from five mice of each group. Horizontal lines indicate mean.

Level of Ig subclass in H1R^−/− mice before and after immunization with the T cell–dependent antigen, OVA. (A) Levels of serum Ig subclass in unimmunized mice. Serum Ig levels in 8–10-wk-old H1R^−/− mice (−/−) and their wild-type littermates were determined by isotype-specific ELISA. •, control (+/+); ○, mutant (−/−) mice. Shown are the results from five mice of each group. (B) Levels of anti-OVA antibody titers of each Ig isotype after secondary immunization. Serum samples were collected 2 wk after the second immunization. Titers of OVA-specific antibodies were determined by isotype-specific ELISA. Serum antibody levels are expressed as OD₄₅₀. Shown are the results from five mice of each group. Horizontal lines indicate mean.