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. 1999 Feb 15;189(4):615–625. doi: 10.1084/jem.189.4.615

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Predicted 835 amino acid sequence of the mouse Tlr4 gene. Amino acid positions are numbered from the start of the 2.5-kb ORF. The protein sequences of mouse Tlr4 (top) and human TLR4 (bottom; EMBL/GenBank /DDBJ accession no. U93091) are aligned. Amino acid identity is shown between the two sequences; a + represents similarity between the corresponding pair of amino acid residues. The predicted transmembrane domain is underlined. The position of the proline to histidine substitution at position 712 associated with LPS hyporesponsiveness is highlighted in bold. These sequence data are available from EMBL/ GenBank/DDBJ under accession no. AF110133.