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. 1999 Mar 1;189(5):821–829. doi: 10.1084/jem.189.5.821

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Poly I:C primes for a Th1 response. IFN-γ and IL-4 production by polyclonal T cell lines generated by stimulating purified CD45RA⁺CD4⁺ T cells with allogeneic DCs. A, TNF-α–matured DCs; B, poly I:C-matured DCs; C, poly I:C-matured DCs in the presence of neutralizing antibodies to IL-12. A strong Th1 response was also obtained with LPS-matured DCs (data not shown). In some experiments both anti–IL-12 and anti–IFN-α antibodies were required to inhibit Th1 development. Anti–IL-12 antibodies did not affect polarization induced by TNF-α–matured or immature DCs.