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. 1999 Jun 21;189(12):1939–1946. doi: 10.1084/jem.189.12.1939

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IL-13 expression in the lymph node of a patient with Hodgkin's disease. Paraffin sections of the diagnostic formalin-fixed cervical lymph node from a 53-yr-old male patient with Hodgkin's disease of the nodular sclerosis subtype, clinical stage IIA. (A, B, and D) In situ hybridization for IL-13, black silver grains denote IL-13 expression. (A) Multinuclear Reed-Sternberg and Hodgkin cells express IL-13. (B) Mitotic H/RS cell with a positive IL-13 signal. (C–E) Serial sections were stained for CD30 (C) or CD15 (E) or hybridized with an IL-13 antisense probe (D). The photographs are taken from the same area of three consecutive serial sections and illustrate the expression of CD30, IL-13, and CD15 by the same cell. Original magnification: A, ×400; B, ×1,000; C–E, ×200.