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. 1999 Jun 21;189(12):1885–1894. doi: 10.1084/jem.189.12.1885

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Proliferation occurs in primary PBMC cultures from reactors and nonreactors in response to peptides FC1P 1, FC1P 2, and FC1P 3. T cell reactivity to FC1P in (A) subjects developing LARs and (B) nonreactors. Delta counts per minute (Δcpm) from PBMC proliferating to peptides FC1P 1, 2, and 3 at up to three concentrations. All patients reacted to tuberculin (PPD; positive control) with a mean Δcpm of 65,112 (data not shown). Background counts ranged from 680 to 4,465 cpm. •, statistically significant proliferative responses (see Materials and Methods) compared with background; ○, nonstatistically significant proliferative responses. Each peptide was capable of eliciting a proliferative response, in a dose-dependent fashion, in individuals from both groups (responders, n = 7; nonresponders, n = 19); however, none of the peptides induced proliferation in all individuals.

Proliferation occurs in primary PBMC cultures from reactors and nonreactors in response to peptides FC1P 1, FC1P 2, and FC1P 3. T cell reactivity to FC1P in (A) subjects developing LARs and (B) nonreactors. Delta counts per minute (Δcpm) from PBMC proliferating to peptides FC1P 1, 2, and 3 at up to three concentrations. All patients reacted to tuberculin (PPD; positive control) with a mean Δcpm of 65,112 (data not shown). Background counts ranged from 680 to 4,465 cpm. •, statistically significant proliferative responses (see Materials and Methods) compared with background; ○, nonstatistically significant proliferative responses. Each peptide was capable of eliciting a proliferative response, in a dose-dependent fashion, in individuals from both groups (responders, n = 7; nonresponders, n = 19); however, none of the peptides induced proliferation in all individuals.