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. 1999 Jan 18;189(2):253–264. doi: 10.1084/jem.189.2.253

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Engagement of one TCR with antagonist peptides does not inhibit the activation through a second independent TCR. Analyzing cells simultaneously expressing both Vα2Vβ5 and Vα2Vβ10 TCRs on the cell surface, the Vα2Vβ5-specific antagonist peptides, E1 and P7, inhibited the IL-2 production (A) and the TCR downregulation (B) induced by the Vα2Vβ5-specific antigenic peptide, SIINFEKL. However, the Vα2Vβ5-specific antagonists, E1 and P7, did not inhibit the IL-2 response (C), nor the TCR downregulation (D) induced by the Vα2Vβ10-specific antigen, SSIEFARL. The IL-2 response (A and C) and TCR downregulation (B and D) were assayed in the same experiment. The data are representative of six separate experiments.