Table I.

Depletion of Macrophages Results in the Prevention of Insulitis in NOD Mice

Treatment*		Insulitis grade‡
		0		1		2		3		4
						%
PBS		3		9		11		35		42
lip-Cl2MDP		91		5		3		1		0

^* 200 μl of lip-Cl₂MDP per mouse was injected intraperitoneally into female NOD mice weekly from 3 to 20 wk of age.  

^‡ At 25 wk of age, five randomly selected nondiabetic mice were killed and at least 20 islets per mouse were examined. Grade: 0, normal islets; 1, mononuclear infiltration, largely in the periphery, in <25% of the islets; 2, 25–50% of islets infiltrated; 3, >50% of islets infiltrated; 4, small, retracted islets with few mononuclear cells.