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. 1999 Apr 5;189(7):1111–1120. doi: 10.1084/jem.189.7.1111

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Course of L. major LV39 infection in BALB/c mice immunized with altered LACK ligands. (A) Groups of eight nonthymectomized BALB/c mice (▪) were immunized in the hind footpads with either vehicle control or 25 μg recombinant LACK, LACK-K164, LACK-N164, LACKΔ41, or OVA. Mice were infected in one footpad the following day with L. major LV39 stationary phase promastigotes and the size of the local lesion quantitated as infected minus noninfected footpads using a metric caliper. A cohort of age-matched, resistant C57BL/6 mice was included as shown (▵). Subgroups of resistant and susceptible mice occurred after immunization with LACK and LACK-N164. Results were comparable in two independent infections. (B) Groups of 7–8 BALB/c mice were thymectomized (▵) at 8 wk of age and immunized and infected with L. major LV39 promastigotes as above. Control adult thymectomized BALB/c mice (BALB/c ATx) remained as susceptible as nonthymectomized BALB/c mice (▪), as shown in the first panel. Subgroups of resistant and susceptible mice occurred after immunization with LACK. Results were comparable in two independent infections.

Course of L. major LV39 infection in BALB/c mice immunized with altered LACK ligands. (A) Groups of eight nonthymectomized BALB/c mice (▪) were immunized in the hind footpads with either vehicle control or 25 μg recombinant LACK, LACK-K164, LACK-N164, LACKΔ41, or OVA. Mice were infected in one footpad the following day with L. major LV39 stationary phase promastigotes and the size of the local lesion quantitated as infected minus noninfected footpads using a metric caliper. A cohort of age-matched, resistant C57BL/6 mice was included as shown (▵). Subgroups of resistant and susceptible mice occurred after immunization with LACK and LACK-N164. Results were comparable in two independent infections. (B) Groups of 7–8 BALB/c mice were thymectomized (▵) at 8 wk of age and immunized and infected with L. major LV39 promastigotes as above. Control adult thymectomized BALB/c mice (BALB/c ATx) remained as susceptible as nonthymectomized BALB/c mice (▪), as shown in the first panel. Subgroups of resistant and susceptible mice occurred after immunization with LACK. Results were comparable in two independent infections.