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. 1999 Apr 5;189(7):1157–1162. doi: 10.1084/jem.189.7.1157

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Treatment with anti–CTLA-4 mAb augments the accumulation and activation of adoptively transferred CD8⁺ T cells in the lymph nodes of mice immunized with DC. (A) Numbers of Vα2⁺Vβ8⁺CD8⁺ cells were determined in the lymph nodes of experimental mice (n = 4–8) 5 d after immunization with DC and are presented as the average ± SE fold increase in the total number of Vα2⁺Vβ8⁺CD8⁺ T cells over the corresponding nonimmunized adoptive transfer controls. Combined results from two experiments are shown. Numbers of Vα2⁺Vβ8⁺CD8⁺ T cells in nonimmunized adoptive transfer controls varied between 3 × 10⁴ and 10⁵ over two different experiments. Mice received treatment with anti–CTLA-4 mAb or control IgG as indicated. (B) Representative stainings from mice immunized with DC + Ag. CD44 expression on gated Vα2⁺Vβ8⁺ cells was determined by triple staining and FACS^® analysis.

Treatment with anti–CTLA-4 mAb augments the accumulation and activation of adoptively transferred CD8⁺ T cells in the lymph nodes of mice immunized with DC. (A) Numbers of Vα2⁺Vβ8⁺CD8⁺ cells were determined in the lymph nodes of experimental mice (n = 4–8) 5 d after immunization with DC and are presented as the average ± SE fold increase in the total number of Vα2⁺Vβ8⁺CD8⁺ T cells over the corresponding nonimmunized adoptive transfer controls. Combined results from two experiments are shown. Numbers of Vα2⁺Vβ8⁺CD8⁺ T cells in nonimmunized adoptive transfer controls varied between 3 × 10⁴ and 10⁵ over two different experiments. Mice received treatment with anti–CTLA-4 mAb or control IgG as indicated. (B) Representative stainings from mice immunized with DC + Ag. CD44 expression on gated Vα2⁺Vβ8⁺ cells was determined by triple staining and FACS^® analysis.