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. 1999 Apr 5;189(7):1033–1042. doi: 10.1084/jem.189.7.1033

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Regression of primary autoreactivity during progression of EAE. By 12 wk after immunization, splenocyte proliferative responses to all priming determinants invariably declined from peak levels reached between 2 and 8 wk and were not evident in most animals immunized with either (a) PLP 104–117 or (b) PLP 178–191. (c) As shown in the graph, PLP 139–151–immunized mice showed a delayed pattern of declining responsiveness to the priming determinant. By 16 wk after immunization responses to PLP 139–151 were detectable but at levels substantially lower than those observed at 2–12 wk. Each experimental time point represents the mean response of 5–6 mice. Error bars show ± SEM.