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. 1999 Apr 5;189(7):1033–1042. doi: 10.1084/jem.189.7.1033

Figure 5.

Figure 5

Emergence of epitope spreading cascades during progression of EAE. Progression of EAE coincided with regression of primary autoreactivity and with the concurrent emergence of epitope spreading cascades. (a) SWXJ mice primed with PLP 104–117 showed neo-autoreactivity to MBP 87–99 and PLP 139–151 followed by responsiveness to PLP 178–191. (b) Mice primed with PLP 178–191 showed epitope spreading to PLP 139–151 and MBP 87–99. (c) Mice primed with PLP 139–151 showed sequential recognition of MBP 87–99 and PLP 178– 191. In all cases, variations in positive control responses to H37RA showed no correlation with the changes observed in primary and spreading autoreactivities. Error bars show ± SEM.