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Impaired IL-18–induced NK cytotoxicity in IRAK-deficient mice. IRAK-deficient [IRAK(−)] and wild-type mice were injected intraperitoneally with PBS, 1 μg IL-18, or 200 μg poly(I):poly(C) for 2 d consecutively. Spleen cells were assayed for NK cytotoxic activity against 51Cr-labeled YAC-1 target cells.
