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. 1999 Apr 5;189(7):1121–1128. doi: 10.1084/jem.189.7.1121

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Role of IL-12 and IFN-γ in the induction of IL-12R expression in the spleen. C57BL/6 mice were injected intravenously with α-GalCer. 4 h after the injection, spleen cells were prepared and their expression of IL-12Rβ1 () and IL-12Rβ2 (▪) mRNA was measured by quantitative RT-PCR. The IL-12R mRNA levels are presented as an induction index, as described in Materials and Methods. The blocking effect of anti–IL-12 mAb and anti–IFN-γ mAb was determined by injection of these mAbs (500 μg/mouse i.p.) into the mice 1 and 0 d before the treatment with α-GalCer. The bars represent mean ± SE of triplicate samples.