Figure 8.
A model for how GrpL may function in TCR- mediated signal transduction. Results from our study demonstrate that GrpL and Grb2 may differentially associate with SLP-76, LAT/pp36/p38, and Sos1/2, respectively. The preferential interaction between GrpL and SLP-76 suggests that GrpL may play a role in the regulation NF-AT pathway during TCR-mediated T cell activation.