Table I.

Clinical Parameters in (PLSJL/J)F1 Mice Immunized with Microbial Mimicry Peptides and Challenged for EAE Induction with gpSCH

IFA immunization*		EAE challenge		Percentage of incidence		Mean day of disease onset		Mean peak disease severity
IFA alone		gpSCH		100		9 ± 1		5
MBPp85–99 (ENPVVHFFKNIVTPR)		gpSCH		95		16 ± 2‡		3.6 ± 0.9‡
HPV 7 (IGGRVHFFKDISPIA)§ ‖		gpSCH		60		17 ± 2‡		2.3 ± 1.2‡
HPV 13 (IGGRVHFFKDISPIS)		gpSCH		60		16 ± 3‡		2.3 ± 0.4‡
HPV 40 (IGGRVHFFRDISPIG)		gpSCH		20		21¶		1¶
Bacillus subtilis ORF (RKVVTDFFKNIPQRI)		gpSCH		0		0¶		0¶
HPV 32 (IGSRVHFFHDISPIT)		gpSCH		20		13¶		3‡

^* Groups of 20 animals were used for data analysis.  

^‡  P < 0.01 by Student's t test compared with immunization with IFA alone.  

^§ Amino acid homologies with the peptide MBPp87–99 are in bold.  

^‖ Note that the HPV 7 sequence we use is three amino acids shorter at its NH₂ terminus than that used by Ufret-Vincenty et al. (1).  

^¶  P < 0.001 by Student's t test compared with immunization with MBPp87–99.