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. 1999 Apr 19;189(8):1265–1274. doi: 10.1084/jem.189.8.1265

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The COOH-terminal portion of HLA-C is a determinant for inhibition of NK cell cytotoxicity. NK cell lines 986 (A) and I (B), selected by their susceptibility to inhibition by the expression of HLA-C proteins in 721.221 cells, were assayed for their capacity to be inhibited by expression of HLA-Cw6/G end and HLA-Cw7/G end at various E/T cell ratios. The data set shown is representative of three independent experiments using two or three independently transfected target cell lines for each class I MHC protein variant, except HLA-Cw7 and -G, for which only one transfectant was used.