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. 1999 Apr 19;189(8):1265–1274. doi: 10.1084/jem.189.8.1265

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NK clones inhibited by target cell expression of HLA-Cw6 differ in their sensitivity to the transmembrane sequence of the protective class I MHC protein. NK clone 4 (A), NK clone 2 (B), and NK clone 82 (C), selected by their susceptibility to be inhibited by target cell expression of HLA-Cw6, were assayed for lysis of HLA-Cw6/TM G and -Cw6/C309W transfectants at the various E/T cell ratios shown. Data sets shown are representative of two independent experiments performed. Another independently made HLA-Cw6/TM G transfectant gave similar results (not shown). The transfectant expressing HLA-Cw6/G end behaved similarly to that expressing -Cw6/TM G or -Cw6/C309W (not shown).